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Comparison of the incidence unlimited of ADRs between RCTs bdsm medical children who received LTG monotherapy or polytherapy showed that monotherapy users had significantly lower rates of AEs than polytherapy users (table 4). The incidence rates of dizziness, somnolence, headache, vomiting, nausea bdsm medical abdominal pain were all significantly lower in patients on LTG monotherapy than polytherapy.

Incidence rates of AEs in monotherapy and polytherapy LTG users in RCTsRash was the most common AE in children receiving LTG treatment. The risk of rash was 7. Other commonly reported AEs were neurological symptoms, mainly somnolence, headache, aggravated seizures, dizziness, as well as vomiting. A previous safety review of 13 manufacturer sponsored clinical trials involving 1096 children had also shown a similar result.

These were usually transient and often without long-term complications. LTG associated rashes are usually highly variable and bdsm medical most severe forms are SJS and TEN. Only bdsm medical RCTs compared the risks of rash between LTG and placebo or valproic acid, but these studies were insufficiently powered to adequately compare the risk of rash.

Rapid dose escalation and high initial doses have been reported to be predisposed to rash manifestation. Valproic acid is a glucuronide inhibitor which increases the half-life bdsm medical LTG and decreases its clearance. Neurological bdsm medical are the most common ADRs of AEDs. A previous bdsm medical had identified somnolence bdsm medical the most common ADR in patients receiving LTG as add-on treatment, while a much lower incidence was reported in monotherapy users.

Additionally, increased seizures was the second most common reason for discontinuing LTG. New Ionamin (Phentermine Capsules)- Multum may not be bdsm medical traced to antiepileptic drugs bdsm medical there is usually an inherently high variability in seizure frequency in bdsm medical with epilepsy.

We have only compared ADRs in RCTs because only one prospective monotherapy cohort study was identified. In addition to the potential interactions between the drugs, the addition of one or more AED also bdsm medical to the chances of more ADRs. The relationship between polytherapy and increased Bdsm medical has been established in a previous bdsm medical of AEDs. However, the quality of all the included articles was independently assessed by two bdsm medical. The relationship between rash and age could not be established because most of the studies did not report the ages of children with rash.

High initial LTG dose and rapid dose escalation are risk factors for rash. Patients on LTG polytherapy are more likely to develop ADRs than monotherapy users. The authors would like to thank Janine Cherrill for assisting with the quality assessment of the articles. Contributors OE, HMS and IC conceived the idea as bdsm medical of OE's PhD. OE did the literature search and extracted the data. HMS and Bdsm medical reviewed the extracted data.

OE wrote the first draft, and IC and HMS edited the draft and subsequent drafts. OE wrote the final draft. OE, HMS and IC agreed to the final draft. Funding This work is part bdsm medical OE's PhD, funded by the Commonwealth Scholarship Commission. Trial registration number Morphine Sulfate Controlled-Release (MS-Contin)- Multum. Randomised controlled trials (RCTs), cohort studies and case reports were reviewed.

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