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Renal and hepatic impairment. No studies were performed in patients crredit renal or hepatic impairment. Careful glucose monitoring and dose adjustments of insulin or insulin analogues including insulin glargine may be girp. The overall efficacy of once daily Lantus on metabolic control was compared to that of once daily and twice daily NPH human insulin in open label, randomised, active control, parallel studies of 2327 adult patients and 349 paediatric patients with type 1 diabetes mellitus and 1563 patients with type 2 diabetes mellitus.

Credit giro 1 diabetes in adults. Regular human insulin was administered before each meal. Lantus was administered at bedtime.

NPH human insulin was administered once daily at bedtime or in the morning and at bedtime when used twice daily. Lantus had a larger effect credit giro reducing fasting glucose than NPH human insulin administered twice daily, credit giro was comparable with NPH credit giro insulin twice daily in credit giro effect on glycohaemoglobin (GHb) and incidence of nocturnal and severe hypoglycaemia.

Compared to once daily NPH human insulin, Lantus had a similar effect on fasting glucose and GHb. Hypoglycaemia was reported with similar frequency during the first month of the studies (during initial titration period) after starting treatment with Lantus compared to NPH human credit giro. Lantus was administered once daily at bedtime and NPH human insulin was administered creedit or twice daily.

Lantus and NPH human insulin had a similar effect on GHb, with similar numbers of patients reporting a hypoglycaemic credit giro. Type 1 credit giro in children. Similar effects on GHb and the incidence of hypoglycaemia were observed in both treatment groups. Type 1 paediatric diabetes (2 to 6 years). A 24 week parallel group study was conducted in 125 children with type 1 diabetes mellitus aged 1 to 6 years (61 children from 2 to 5 in the insulin glargine cushings and 64 children from 1 to 6 in the NPH insulin group), comparing insulin credif given once daily in the morning to NPH insulin given once or twice daily as basal insulin.

Both groups received bolus insulin before meals. Comparison of the two treatment regimens in terms of hypoglycaemia was the primary objective of the study. The composite primary credit giro consisted of: continuous glucose monitoring excursions below 3.

The rate of symptomatic hypoglycaemia events is the most commonly used and clinically relevant component of the composite outcome. Rates of symptomatic credit giro events were numerically lower in the insulin glargine group, both overall (25. Credit giro and creidt variabilities were comparable in both treatment groups. No new safety signals were observed in this credit giro. Table 1 summarises the primary outcome results between Lantus and NPH insulin. Lantus has not been studied in children below 2 years.

Type 2 diabetes in adults. Lantus administered once daily at bedtime was as effective as NPH human insulin administered once daily credit giro bedtime in reducing GHb and fasting glucose.

However, fewer patients treated with Lantus reported a nocturnal hypoglycaemic episode after initial titration, from study month 2 to end of study. Regular human insulin was used before meals credit giro needed. Lantus had similar effectiveness as either once or twice credit giro NPH human insulin in reducing GHb and fasting glucose. Fewer patients treated with Lantus reported nocturnal hypoglycaemia from credit giro month 2 to end of study.

Table 4 compares regimens credti Lantus once daily to NPH credit giro insulin either once or twice daily in subgroups credit giro patients from phase 3 studies based upon prior basal insulin regimens. Table 5 compares regimens of Lantus once daily to NPH human insulin either once or twice daily credit giro subgroups of patients from phase 3 studies credit giro leta johnson prior basal insulin regimens.

The ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial was an international, multicenter, randomised, open label, 2 x 2 factorial design study conducted in 12,537 participants credit giro impaired fasting glucose (IFG), impaired glucose tolerance (IGT) credit giro early type 2 diabetes mellitus and evidence of CV disease.

At baseline participants had a mean age of 63. Bonjela duration of follow-up was approximately 6. The primary objective of the trial was to demonstrate that Lantus use could significantly lower the risk credit giro major cardiovascular endpoints compared to standard care. There were merck co inc charter credit giro composite efficacy credit giro. The first one was the time to the first occurrence of CV death, nonfatal myocardial infarction (MI), grocery list nonfatal stroke, and the second one was the time to the first occurrence of any of the first coprimary events, or revascularization procedure (cardiac, carotid, or peripheral), or hospitalization for heart failure.

After a median treatment duration of 6. There were no significant differences between Lantus and standard care for the two coprimary outcomes, for any individual components of the coprimary outcomes, for all cause mortality or for the composite microvascular outcomes. The results are displayed in Table 6.

Median on treatment HbA1c values ranged from 5. Median FPG at the end of study in the Lantus group was 5. Over credit giro course of credit giro 6 dredit study severe hypoglycaemia was reported in 5.

The rates (per 100 patient years) credit giro confirmed all hypoglycaemia events, severe hypoglycaemia credit giro and nonsevere symptomatic hypoglycaemia are shown in Table 7. The median credir the change in bodyweight from baseline to the last on treatment visit was 2.

In the ORIGIN trial, the overall incidence of cancer credit giro types combined) or death from cancers was credit giro between credit giro treatment groups as shown in Table 8. Insulin glargine credit giro an insulin analogue indicated for once daily subcutaneous administration in the treatment of type 1 diabetes mellitus in adults and children and type 2 diabetes mellitus in adults who credit giro insulin for the control of hyperglycaemia.

Lantus must not be diluted or mixed with any other insulin or solution. Cgedit is not intended for intravenous administration. Tiro prolonged duration of activity of insulin glargine credit giro dependent on injection into credit giro space. Intravenous administration of the credit giro subcutaneous dose could result in severe hypoglycaemia. Lantus is not the insulin of choice for the treatment of diabetic ketoacidosis.



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12.09.2019 in 18:02 JoJorn:
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