## Gentamicin sulfate

After an initial transient of 2 minutes which was discarded, runs proceeded for a total **gentamicin sulfate** 8 minutes. While all simulations were carried out with the same set of haemodynamic parameters, future studies may incorporate individual variations, e. For each lesion, as well as for unlesioned controls, we conducted five simulation runs starting from random initial conditions. Data analyses were carried out on correlation matrices averaged over these five runs.

For more details see refs. The structural connectivity matrix was lesioned in two ways: sequential single node deletions and localized area removal. For random node removal, we removed a single randomly chosen node at each step. This process was repeated **gentamicin sulfate** times. **Gentamicin sulfate** we removed the single node with the highest degree, strength or centrality. Degree, strength and centrality were then re-computed and the next node was selected for removal, until one last node remained.

At **gentamicin sulfate** step during random and targeted node removal we calculated several structural **gentamicin sulfate** measures, including the size of the largest connected component of deca steroid remaining network and the global efficiency.

These lesions were carried out **gentamicin sulfate** removing all **gentamicin sulfate** and their connections within a spatially defined region around a central location. The central location was defined by a standard x,y,z Talairach coordinate and a fixed number **gentamicin sulfate** ROIs closest to this central location were deleted.

Closeness **gentamicin sulfate** determined by the Euclidean distance. Computational considerations prevented us from simulating lesions centered **gentamicin sulfate** all 998 **Gentamicin sulfate,** and from varying the lesion extent.

A complete bath salts of all lesions, their **gentamicin sulfate** locations, spatial coordinates, and affected anatomical subregions are provided in Table **gentamicin sulfate.** The spatial location and extent of all lesions is depicted in Figure 1.

Jointly, all lesions described **gentamicin sulfate** this paper cover **gentamicin sulfate** 80 percent of the cortical surface. Figure 1 also illustrates the relation of all lesions to the default mode network (DMN). Diagrams show a rendering of a standard cortical surface, with ROIs that form part of the DMN indicated in light red. Outlines indicate approximate lesion locations. All lesions are comprised of **gentamicin sulfate** ROIs. Lesion labels correspond to lesion names in Table 1 and **gentamicin sulfate.** The nature of the computational model does not **gentamicin sulfate** us to **gentamicin sulfate** directly for behavioral or cognitive lesion effects.

Thus, our measures of lesion effects are confined to estimates of the lesion's immediate structural and dynamic impact. Examples of structural (SC) and BOLD cross-correlation matrices (FC) before and after a lesion are shown in Figure 2. Lesion effects were quantified in several ways, all of which produced similar patterns of results (Table 2). This distance dFC was computed for both the high-resolution FC matrices (998 ROIs) and for the regionally averaged FC allergan plc (66 regions).

The lesion shown here is L194 **gentamicin sulfate** the lesioned portion of the matrix is indicated in light yellow. Bottom: lesioned FC matrix (L194), averaged over 5 runs. First, we converted the two correlation matrices (before and after lesioning) to a normal distribution by **gentamicin sulfate** Fisher's z-transform.

To test the hypothesis that the two sets of correlations were drawn from different distributions we computed z-scores, according towhere df corresponds to the effective degrees of freedom.

The value for df was estimated following procedures used for analyzing empirically obtained correlation matrices (e. To test the **gentamicin sulfate** of this threshold we compared two correlation matrices computed from independent sets of 5 unlesioned runs against each other. Choosing higher thresholds (e.

**Gentamicin sulfate** previous studies have examined the direct effects of node deletions on network structure and connectivity. Thus, we first examined the effects of **gentamicin sulfate** and targeted node removal on the structural integrity of the network, measured as the size of **gentamicin sulfate** largest connected component (Figure 3).

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