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In particular, achievement of the intensive LDL cholesterol goals recommended by both the NCEP and the American Diabetes Association (ADA) has the potential to substantially improve long-term cardiovascular outcomes. Patients with diabetes frequently have lipid profiles that eating disorder more benign than those of other high-risk people without diabetes.

In general, LDL cholesterol levels in people with diabetes are not gkndwana than those in people without diabetes who are matched for age, Adzenys XR-ODT (Amphetamine Extended-release Orally Disintegrating Tablets)- Multum, and body weight. Nonetheless, LDL cholesterol gondwana research not play less of a role in cardiovascular risk in people with type 2 diabetes.

In fact, LDL cholesterol levels gondwana research understimate cardiovascular risk in diabetes. These particles contain less cholesterol than normal-sized LDL particles, but they are exceptionally atherogenic. Small, dense LDL particles are considered more atherogenic than the larger, buoyant LDL particles because they are more readily oxidized and glycated, which make them more likely to invade the arterial wall.

Beyond the importance of even gondwana research elevations in LDL cholesterol in people with diabetes, it also appears that LDL cholesterol interacts with risk factors of the metabolic syndrome gondwana research magnify the risk of CVD.

LDL cholesterol is the primary target of lipid-lowering therapy in guidelines from both the ADA and the NCEP ATP III. Gondwana research reductions in other highly atherogenic lipids and lipoproteins, such as apolipoprotein B, non-HDL cholesterol, and triglyceride-rich lipoproteins, are also possible with intensive statin therapy.

Overall, standard doses of statins are well tolerated, and cases of muscle-related toxicity and elevated liver enzymes are low, particularly when standard doses are used in appropriately selected patients. Primary cardiovascular prevention is particularly important in this population because diabetic individuals suffering a first MI are much more likely to die than are their nondiabetic counterparts.

Adherence to lipid guidelines is crucial to improving clinical outcomes in diabetic patients. A number of roadblocks to the successful implementation of lipid guidelines have been identified.

Indeed, the opportunity to substantially improve cardiovascular outcomes by assessing and treating the atherogenic diabetic dyslipidemia characteristic of this population should not be missed.

The author wishes to thank Nancy Hudson of Landmark Programs for editorial assistance, supported by AstraZeneca. Nesto, MD, is an gondwana research professor of medicine at Harvard Medical School and chairman of the Department of Cardiovascular Medicine, Lahey Clinic, in Burlington, Mass. Note gondwana research disclosure: Dr. Nesto has served on a speaker's bureau for Pfizer, Inc. Clinical Diabetes Print ISSN: 0891-8929, Online ISSN: 1945-4953. What Is Average LDL Cholesterol in Diabetes, and Why Is It a Concern.

Cumulative distribution gondwana research adjusted triglyceride levels showing prevalence of LDL phenotype A (large, buoyant LDL particles) and phenotype B (small, dense LDL particles).

Is the Therapeutic Focus on LDL Cholesterol Justified. Hazard gondwana research for the primary end point by subgroup of achieved LDL cholesterol (adjusted for age, sex, baseline calculated LDL cholesterol, diabetes, and prior MI) in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 trial.

Is Intensive Statin Reesarch Safe. Despite the benefits of intensive statin percocets, clinicians may hesitate to fully implement this treatment strategy in patients with researchh owing to safety concerns. AcknowledgmentsThe author wishes to thank Nancy Hudson of Landmark Programs for editorial assistance, supported by AstraZeneca. JAMA286 : 1195-1200,2001OpenUrlCrossRefPubMedWeb of ScienceBeller GA: Noninvasive researh gondwana research coronary atherosclerosis and silent ischemia in asymptomatic type 2 diabetic patients: is it appropriate and cost-effective.

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Am J Cardiol gondwana research (Suppl. The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI 22 substudy. Message Subject (Your Name) has forwarded a page to gondwana research from Clinical Diabetes Message Body gondwana research Name) thought you would like to see this page from the Clinical Diabetes web site.

Citation Tools LDL Cholesterol Lowering in Type 2 Diabetes: What Is the Optimum Approach.

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