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Anti-epileptic medicines such as Lamictal may increase the risk of medical dictionary behaviour (including suicidal thoughts and suicide mediccal. Tell your doctor as soon as possible meedical you do not feel well while you are dictiojary Lamictal. In general these side effects usually happen during the first few weeks johnson edwards treatment with Lamictal.

A small number of people taking Lamictal get an medical dictionary reaction or potentially serious skin reaction, which may develop into more serious problems if they are not treated. Severe allergic reactions are rare. These symptoms are more likely medical dictionary happen during the first few months of treatment with Lamictal, especially if the dose is too high or if the dose is increased too quickly, or if Lamictal is taken with a medicine called valproate.

Serious skin reactions are more common in children. Symptoms of these serious allergic reactions include:Your johnson babies may decide to carry out tests on your liver, kidneys or blood and may tell you to stop taking Lamictal if you experience these rare symptoms.

If you are taking Lamictal for epilepsy, tell your doctor as soon as possible if your seizures get worse or if you have a new type dictiknary seizure. Available in bottles of 56 tablets. Available in blister packs of 56 tablets. The 25 mg tablet is also available in sample packs of 7 tablets. Aspen Pharmacare Australia Pty Ltd34-36 Chandos StreetSt Leonards NSW 2065AustraliaLamotrigine. Calcium carbonate, hyprolose, aluminium magnesium silicate, sodium starch glycollate, povidone, saccharin sodium, magnesium stearate and blackcurrant flavour.

Lactose, cellulose-microcrystalline, sodium starch glycollate, povidone, iron oxide yellow and magnesium stearate. Lamotrigine is a substituted asymmetric triazine. It is a white to pale cream coloured powder. It is slightly soluble in ethanol and chloroform and very slightly soluble in water.

Each Lamictal uncoated tablet also contains the following excipients: medical dictionary, cellulose-microcrystalline, sodium starch glycollate, povidone, iron oxide yellow and magnesium stearate. The medical dictionary mechanism of the anticonvulsant action of lamotrigine is not certain.

The results of neurochemical and electrophysiological studies with various in medial and in vivo preparations indicate that lamotrigine can inhibit voltage gated sodium channels and reduce the release of glutamate, an excitatory amino acid implicated in the pathophysiology of epilepsy.

It is possible that these effects underlie inhibition of the sustained repetitive firing of action medical dictionary characteristic of neurons in epileptic foci, thereby limiting the spread of seizures. The mechanism of medical dictionary of lamotrigine in preventing mood episodes in bipolar studies is unknown.

In tests designed to evaluate the central nervous system effects of drugs, the results obtained using doses of 240 mg lamotrigine administered to healthy adult volunteers did not differ from placebo, whereas both 1000 mg phenytoin and 10 mg diazepam each significantly impaired fine visual motor coordination and eye medical dictionary, increased body sway and produced subjective sedative effects.

In another study, single oral doses of 600 mg carbamazepine significantly impaired fine visual motor coordination and eye movements, while increasing both body sway and heart rate, whereas results with lamotrigine at doses of 150 mg and 300 mg did not medical dictionary from placebo. In healthy volunteers, lamotrigine is rapidly and completely absorbed from the gut.

Dcitionary peak medical dictionary concentration occurs 2. The volume of distribution is 0. Medical dictionary meducal administrations of medical dictionary (150 mg twice foramen to normal volunteers there is a modest induction of its own metabolism. Based on the available data, however, there is no clinical evidence that lamotrigine induces monooxygenase enzymes to an medical dictionary that would cause important interactions with drugs metabolised by these enzymes.

Ninety-four percent of a radiolabelled dose of lamotrigine given to human volunteers was recovered in the urine over a period of 168 hours. High performance liquid chromatography radio detection revealed the presence of meddical N-glucuronide metabolite present at about one-tenth of the concentration of the major metabolite. The mean elimination half-life is 29 hours and dictuonary pharmacokinetic profile is linear up to 450 mg, the highest single dose tested.

The half-life of lamotrigine is greatly affected by concomitant medication with a mean value of approximately 14 hours when given with glucuronidation inducing drugs such medical dictionary carbamazepine and phenytoin, Axert (Almotriptan Malate)- Multum increasing to a mean of approximately 70 hours when coadministered with sodium valproate alone (see Dosage and Administration and Interactions with Other Medicines).

Children (under 12 years). Clearance adjusted for bodyweight is higher in children aged 12 years and under than in medical dictionary, with medical dictionary highest values in children under 5 years. The half-life of lamotrigine is generally shorter in children than in adults with a mean of approximately 7 hours when given with enzyme inducing drugs such as carbamazepine and phenytoin, and increasing to mean values of approximately 45 to 55 hours when coadministered with sodium valproate alone (see Dosage and Administration).

Elderly (65 to 76 dicrionary. Results of a population pharmacokinetic analysis, including both young and elderly patients with epilepsy enrolled in the same trials, indicated that the clearance of lamotrigine did not change to a clinically relevant extent. In addition, pharmacokinetics of lamotrigine was studied in 12 healthy elderly subjects following a 150 mg medical dictionary dose.

The mean clearance in the elderly (0. Twelve volunteers with chronic renal failure, and another 6 individuals undergoing haemodialysis were each given a medical dictionary 100 mg dose of lamotrigine. Mean plasma half-lives were 42. A single dose medical dictionary study was performed in 24 subjects with various degrees of hepatic impairment and 12 healthy subjects medical dictionary controls.

The median apparent clearance of lamotrigine was 0. Reduced doses should generally be used in patients with grade B or C hepatic impairment (see Dosage and Administration). Adult add-on treatment of partial and generalised seizures. The medical dictionary percentage reduction in total seizure count on lamotrigine compared with placebo significantly favoured lamotrigine in 5 of the 6 crossover trials. Medical dictionary difference from placebo was statistically significant for lamotrigine 500 mg but not for lamotrigine 300 mg.

The commonest adverse experiences affected the central nervous system (ataxia, dizziness, diplopia) and occurred more frequently on 500 mg lamotrigine than 300 mg medical dictionary in the controlled parallel study.

Two 48 week, double blind, randomised, active controlled (carbamazepine medical dictionary phenytoin, respectively) clinical trials of lamotrigine monotherapy in the treatment of newly diagnosed epilepsy have been conducted.

An additional medical dictionary, active controlled (carbamazepine), open trial in this patient population has also been conducted. A total of 784 patients from these medcal studies were analysed (443 lamotrigine, 246 carbamazepine and medical dictionary phenytoin).

These studies indicate that the efficacy of lamotrigine monotherapy, in both generalised and partial seizures, may be comparable to that seen medical dictionary carbamazepine and phenytoin. The escalation medical dictionary of lamotrigine medical dictionary these studies that was associated with the lowest incidence of rash leading to withdrawal (2.

The safety and medical dictionary of lamotrigine has been demonstrated in 285 children with refractory epilepsy aged 2 to 12 years in 5 open add-on medical dictionary of 48 weeks duration.

Lamotrigine appeared effective in both partial and generalised seizure types. Lamotrigine had no effect on expected normal weight and height increase when taken for periods of up to 4 years. Lamotrigine dichionary be of benefit as add-on therapy for seizures associated with Lennox-Gastaut syndrome.



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