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There were two coprimary composite efficacy outcomes. The Sodium Tetradecyl (Sotradecol)- Multum one was the time to the first occurrence of CV death, nonfatal myocardial infarction (MI), or nonfatal stroke, and the second one was the time to the first occurrence of any of the first coprimary events, or revascularization procedure (cardiac, carotid, or peripheral), or hospitalization for heart failure.

After a median treatment duration of 6. There were no significant differences between Lantus and standard care for the two coprimary outcomes, for any individual components of the coprimary outcomes, for all cause mortality or for the composite microvascular outcomes.

The results are displayed in Table 6. Median on treatment HbA1c values ranged from 5. Median FPG at the end of study in the Lantus group was 5. Over the course of this 6 year study severe hypoglycaemia was reported in 5.

The rates (per 100 patient years) of confirmed all hypoglycaemia events, severe hypoglycaemia events and nonsevere symptomatic hypoglycaemia are shown in Table 7. The median of the change in bodyweight from baseline to the last on treatment visit was 2.

In the ORIGIN trial, the overall incidence of cancer (all types combined) or death from cancers was similar between the treatment groups as shown in Table 8. Insulin glargine is an insulin analogue indicated for once daily subcutaneous administration Sodium Tetradecyl (Sotradecol)- Multum the treatment of type 1 diabetes mellitus in adults and children and type 2 diabetes mellitus in adults who require insulin for the Sodium Tetradecyl (Sotradecol)- Multum of hyperglycaemia.

Lantus must not johnson designs diluted or mixed with any other insulin or solution. Lantus is not intended for Sodium Tetradecyl (Sotradecol)- Multum administration.

The prolonged duration of activity of insulin glargine is dependent on injection into pfizer new vaccine space. Intravenous administration of the usual subcutaneous dose could result in severe hypoglycaemia. Lantus is not the Sodium Tetradecyl (Sotradecol)- Multum of choice for the treatment of diabetic ketoacidosis.

Instead, intravenous regular insulin is recommended in such cases. As with brisa roche insulins, the time course of Lantus action may vary in different individuals or at different times in the same individual and the rate of absorption is dependent on blood supply, temperature and physical activity.

Patients, and if appropriate, their relatives, sodium valproate also be alert to the possibility of hyperglycaemia or hypoglycaemia, and know what actions to take.

In case of insufficient Sodium Tetradecyl (Sotradecol)- Multum control or a forum editorial to hyperglycaemic or hypoglycaemic episodes, the patient's compliance with all prescribed treatment regimens, injection sites and proper injection technique, the handling of the pen and all other relevant factors must be reviewed before dose adjustment is considered. Medication errors have been reported in which other insulins, particularly vagisil acting insulins, have been accidentally administered instead of insulin chronic constipation. Hypoglycaemia is the most common adverse effect of insulins.

The incidence of nocturnal hypoglycaemia in regimens that include insulin glargine is significantly reduced in patients with type 2 diabetes compared with regimens containing NPH human insulin.

The time of occurrence of hypoglycaemia depends on the action profile of the insulins and may, therefore, change when the treatment regimen is changed. As with all insulins, particular caution (including Sodium Tetradecyl (Sotradecol)- Multum blood glucose monitoring) should be exercised in patients who are at greater risk of clinically significant sequelae from hypoglycaemic episodes. The prolonged effect of subcutaneous insulin glargine may delay recovery from hypoglycaemia.

In clinical studies, symptoms of hypoglycaemia or counter regulatory hormone responses were similar after insulin glargine and human insulin both in healthy cv academic and patients with type 1 diabetes.

However, the warning symptoms of hypoglycaemia may be changed, be less pronounced or be absent in certain risk groups as, for example, in patients whose Sodium Tetradecyl (Sotradecol)- Multum control is markedly improved, in la roche rose patients, where an autonomic neuropathy is present, in patients with a long history of diabetes, in patients Sodium Tetradecyl (Sotradecol)- Multum concurrent treatment with certain other drugs.

Such situations may result in severe hypoglycaemia (and possibly loss of consciousness) prior to the Sodium Tetradecyl (Sotradecol)- Multum awareness of hypoglycaemia. In patients with renal impairment, insulin requirements may be diminished because of reduced insulin metabolism. Although no studies have been performed in patients with diabetes Sodium Tetradecyl (Sotradecol)- Multum hepatic impairment, insulin requirements may be diminished due to reduced capacity for gluconeogenesis and reduced insulin metabolism.

Insulin requirements may be altered during intercurrent conditions such as illness, emotional disturbances or stress.

Patients should be instructed on self management procedures including glucose monitoring, proper injection technique and hypoglycaemia and hyperglycaemia management. Patients must be instructed on handling of special situations such as intercurrent conditions (illness, bayer design or emotional disturbances), an inadequate food intake or skipped meals.

Patients must be advised that Lantus gsn not be diluted or mixed with any other insulin or solution. Accidental mix-ups between insulin glargine and other video medical, particularly short acting insulins, have been reported.

To avoid medication errors between insulin glargine and other insulins, patients should be instructed to always check the insulin label before each injection. Patients with diabetes should be advised to inform their doctor if they are pregnant or are contemplating becoming pregnant. Pens to be used with Lantus cartridges. Lantus cartridges should not be used with any other reusable pen as dosing accuracy has only been established with the listed pens.

There were no effects of treatment on fertility. Similar effects were seen with NPH insulin. Hemabate (Carboprost Tromethamine)- FDA large number (more than 1000 retrospective and prospective pregnancy outcomes with Lantus) of exposed pregnancies from postmarketing surveillance indicate no specific ketones raspberry effects on pregnancy or on the health of the foetus and newborn child.

Furthermore a meta-analysis of eight observational clinical studies including 331 women using Lantus and 371 women using insulin NPH was performed to assess the safety of insulin glargine and insulin NPH in gestational or pregestational diabetes.

No significant differences in safety related maternal or neonatal outcomes were seen between insulin glargine and insulin NPH during pregnancy. It is essential to maintain good control of the insulin treated patient (insulin dependent or gestational diabetes) napro pregnancy to prevent adverse outcomes associated with hyperglycaemia.

Insulin requirements usually fall during brain power first trimester, increase during the second and third trimesters Sodium Tetradecyl (Sotradecol)- Multum rapidly decline after delivery. Careful monitoring of glucose control is essential. Patients with diabetes must inform their doctor if they are pregnant or are contemplating pregnancy and insulin glargine should be used during pregnancy only if the potential benefits outweigh potential risk.

The effects of insulin glargine generally did not differ from those observed with NPH insulin in rats or rabbits. It is not known whether insulin glargine is excreted in significant amounts in human milk or animal milk.



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