Green coffee bean

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Based on this theory, we investigated Lpz and Gef combination chemotherapy. Our study showed that green coffee bean Lpz and Gef represents a therapeutic strategy greenn A549 lung cancer both in vitro and in vivo. Treatment with Lpz is usually delivered as pre-treatment in most research papers, including the abovementioned reports. Therefore, we also pre-treated with Lpz in the present study.

A549 cells were pre-treated for 2 h with Lpz and were then treated for an additional 48 h with Gef. We found that combined treatment with Lpz and Gef had a significantly greater efficacy against A549 cells than either drug alone. Furthermore, to beab further insight into the mechanism of operation in solid lung cancers, we used Western blotting to determine the influence of Lpz green coffee bean Gef in combination. We green coffee bean that the combination of Lpz and Gef had green coffee bean synergistic effect against the proliferation of A549 cofgee by triggering apoptosis and cell cycle arrest.

Consistent with the in vitro results, we also found therapeutic activity of Lpz cofvee combination with Gef in human lung cancer xenograft models. Treatment with Lpz or Gef alone led to a reduction in the green coffee bean of the tumors, and the effect was further enhanced when the two treatments were combined. In addition, immunohistochemical analysis of Ki67 showed that green coffee bean cell proliferation was strikingly reduced upon combined administration of Lpz and Gef.

Taken together, these results show that the anticancer efficacy of Lpz combined with Gef is greater than that of either coffse used alone. In addition, all of the results further confirm that Lpz alone or in combination with Gef had positive inhibitory effects on the development and progression of NSCLC.

Furthermore, Lpz in combination with Gef has green coffee bean more potent anticancer activity than either Lpz or Gef alone. Our results provide an experimental foundation for Lpz as a potential treatment for lung cancer.

The raw data supporting the conclusions of green coffee bean article will be made available by the authors, without undue reservation. The animal study was reviewed and approved by Laboratory Animal Center of the Institute of Radiation Medicine, Chinese Academy of Medical Sciences. MJ and DK designed the experiments and acquired funding for green coffee bean study.

XZ, NZ, YH, and XD performed the experiments. XP, WW, Bwan, RW, and YQ provided the technical assistances. XZ and MJ wrote the manuscript.

DK edited the manuscript. This project was supported green coffee bean grants from National Natural Science Foundation of China (81672809 to MJ, 82061148017, 82073890, and 81673464 to DK), and Tianjin Science and Technology Commission (20JCYBJC00670).

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